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Russia approves first COVID-19 Coronavirus prescription drug for sale

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MOSCOW: Russia has approved R-Pharm`s Coronavir treatment for outpatients with mild to moderate COVID-19 infections and the antiviral drug could be rolled out to pharmacies in the country as soon as next week, the company said on Friday. Coronavir`s approval as a prescription drug follows the green light for another Russian COVID-19 drug, Avifavir, in May. Both are based on favipiravir, which was developed in Japan and is widely used there as the basis for viral treatments.

R-Pharm`s announcement is another sign Russia is pushing hard to take a global lead in the race against the virus. It is already exporting its COVID-19 tests and has clinched several international deals for supplies of its Sputnik-V vaccine. R-Pharm said it received approval for Coronavir after Phase III clinical trials involving 168 patients with COVID-19.

The drug was first approved for in-hospital use to treat COVID-19 in July, a government register showed. Coronavir`s trial was comparatively small. The European health regulator on Friday endorsed the use of the steroid dexamethasone in the treatment of COVID-19 patients after a study by UK researchers on several thousand patients.

R-Pharm has started talks with pharmacies about orders, the company`s spokeswoman said, with Coronavir supplies expected to be rolled out in the near future, possibly as soon as next week. Coronavir is made at R-Pharm`s facility in Yaroslavl, about 300 km (186 miles) northeast of Moscow.

Avifavir has been available in hospitals since June but has yet to be supplied to pharmacies. Both are based on the active ingredient favipiravir, which is also the key component in Fujifilm Holdings Corp`s antiviral drug Avigan, approved in Japan as an emergency influenza treatment in 2014.

Trials to test it against COVID-19 are ongoing around the world. Results of a Japanese study in July were inconclusive. It is produced by various Indian generic drugmakers including Lupin, Cipla, and Dr. Reddy`s for use against COVID-19 in India.

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A man in New Zealand finds insects in his Domino’s pizza

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insects

A man in West Auckland, New Zealand says he was left feeling sick after allegedly discovering maggots (insects larva) on his takeaway pizza order from Domino’s.  However, the Domino’s Pizza outlet where Reginald Thalari says he bought the pizza denied the claim.

On Tuesday afternoon, Thalari purchased four pizzas from Domino’s Pizza outlet in Avondale for his employees. But it was after they had eaten a few slices that Thalari alleges they made a stomach-churning discovery.

“It was disgusting. We ordered four pizzas but when we opened the box with pepperoni we saw maggots on the ham.  I felt like spewing, to be honest. If someone says would you like some pizza I think I’ll turn them down next time.”

However, a Domino’s spokesperson said that it is extremely unlikely maggots would have been in store pre-purchase and said it would be “impossible” for eggs to survive the temperature of their ovens.

“Domino’s takes food health and safety extremely seriously, and ensures these standards are upheld through regular audits and inspections of stores throughout the year,” the spokesperson said.

The Domino’s Pizza spokeswoman further said that “Upon learning of this customer’s experience, we contacted the customer directly and have organised a deep clean of the store, as well as for our pest control company to further inspect,”

Input: NZHerald

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US Northeast digs out after massive snow storm, Two dead

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US Snow

People across the U.S. Northeast were digging themselves out on Tuesday after a powerful storm blanketed parts of the region with more than 2 feet of snow, prompting airlines to cancel flights and contributing to at least two deaths.

The nor`easter – an East Coast storm whose winds blow from the northeast – cut power to thousands of households, and halted some subway and train service in and around New York City. It dropped about 30 inches (76 cm) of snow in parts of New Jersey and Pennsylvania and up to 18 inches (46 cm) in New York City.

The snowy weather was expected to continue in parts of the Northeast, with a stretch from upstate New York to northern Maine hit the hardest, the National Weather Service said in its latest forecast on Tuesday. Snow could develop in the Upper Midwest on Wednesday before the storm runs its course, it said.

In Allentown, Pennsylvania, a 67-year-old woman suffering from Alzheimer`s disease was found lying dead in the snow on Monday after wandering away from her home, police said.

A man in Newark, New Jersey, died after being found lying in the snow on Monday, according to police officials, who said the death was not considered suspicious.

In New York City, public transit was coming back to life. Outdoor subway service, which had been suspended, resumed, buses were running on reduced schedules, and the area`s major commuter railroads had resumed partial or full operations.

The city`s LaGuardia Airport and John F. Kennedy International Airport, where flights were canceled on Monday, both said they were working to clear the snow and that they expected activity to pick up later on Tuesday.

The storm prompted widespread closings of schools and COVID-19 vaccination sites. In Connecticut, about 10,000 vaccination appointments were canceled on Monday, with plans to reschedule them for later this week.

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Putin Ordered To Begin Large-scale Coronavirus Vaccination in Russia

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Vladimir Putin

MOSCOW: President Vladimir Putin ordered a large-scale voluntary vaccination program against COVID-19 coronavirus to begin next week across Russia, saying teachers and doctors should be first in line to get the country’s flagship Sputnik V vaccine. Putin gave the order during an online meeting with ministers on Wednesday, a day when Russia, which has the fourth-highest number of recorded infections in the world, registered 589 new daily deaths from the coronavirus.

Putin said Russia will have produced 2 million vaccine doses within the next few days. Sputnik V, one of two Russian-made vaccines to have received domestic regulatory approval so far despite clinical trials being incomplete, requires two injections. A third vaccine is also in the works. Russia said last month that the Sputnik jab was 92% effective at protecting people from COVID-19 according to interim results. “Let’s agree on this – you will not report to me next week, but you will start large-scale vaccination… Let’s get to work already,” Putin told Deputy Prime Minister Tatiana Golikova. “I understand that you’re using very careful language and it’s absolutely right that we are cautious. But I know that industry and the (health) network are in general ready. Let’s take this first step.” Russia has already vaccinated more than 100,000 high-risk people, Health Minister Mikhail Murashko said during a separate presentation to the United Nations about Sputnik V.

According to the presentation, more than 45,000 people are currently participating in Sputnik V trials worldwide. The rise in infections in Russia has slowed since reaching a high on Nov. 27, with 25,345 new daily cases reported on Wednesday. Russia has resisted imposing lockdowns during the second wave of the virus, preferring targeted regional curbs. ‘ABSOLUTE PRIORITY’ The Kremlin earlier gave assurances that Russians were first in line to be vaccinated, with Moscow also discussing supply deals with other countries. “The absolute priority is Russians,” Kremlin spokesman Dmitry Peskov said. “Production within Russia, which is already being developed, will meet the needs of Russians.” Authorities in St Petersburg, which reported 3,684 new infections on Wednesday, ordered bars and restaurants to close from Dec. 30 until Jan. 3, to combat the rise in cases there, the RIA news agency reported.

Museums, theatres, and concert halls would be closed to the public in the city of more than 5 million people for the duration of Russia’s New Year holidays, from Dec. 30 to Jan. 10. In Moscow, a remote learning period for secondary school students was extended beyond Dec. 6 to the end of the year. With 2,347,401 infections, Russia only has fewer COVID-19 cases than the United States, India, and Brazil. It has recorded 41,053 deaths related to COVID-19 since the start of the pandemic.

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