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Bharat Biotech set to launch phase II trial of Covaxin soon

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Preparations are underway for the second phase of the human clinical trial of ‘Covaxin’. Hyderabad-based Bharat Biotech, the maker of India’s indigenous COVID-19 vaccine candidate, had recently received the Indian Council for Medical Research’s (ICMR) approval to conduct trials across 12 medical centers in the country.

S Eswara Reddy, Joint Drugs Controller, in a letter to Bharat Biotech, conveyed the organization’s nod for starting phase II trials in India. These trials will be conducted on 380 volunteers, who will be screened for four days after receiving the vaccine shots.

The Institute of Medical Sciences and SUM Hospital in Bhubaneswar is one of the 12 medical centers chosen by the ICMR for conducting the human trial of the vaccine developed by Bharat Biotech.

EV Rao, Principal Investigator of the trial at the Institute of Medical Sciences and SUM Hospital, Faculty of Medical Sciences, said, “The Phase I of the trial is still continuing and we are planning to start Phase II trial shortly.”

Rao said ‘no side effects’ were found in the vaccine’s phase 1 trial. The blood samples were collected from volunteers after receiving the COVID-19 vaccine to ascertain how effective it was in terms of the development of antibodies.

“Two doses of the vaccine were administered to each volunteer after they were selected through a screening process conducted over a period of three to seven days prior to vaccination. The first dose was administered on Day Zero while and the second dose was given on Day 14,” Rao added.

Blood samples of the volunteers will also be collected on days 28, 42, 104, 194 for estimating the duration of protection, he added. Rao said there was a lot of enthusiasm among people to be a part of the second phase human trial.

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Instagram Down: Giving 5xx Server Error

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Instagram

Update 19 Mar 2021 23:38 IST: Instagram and other apps are now working fine.

Instagram is currently facing downtime and users from all around the world are reporting Instagram Server Down on Twitter. Some users are also facing downtime on WhatsApp and Facebook Messenger.

The Instagram app is showing “couldn’t refresh feed”. and the Instagram website is giving 5xx Server Error.

Server Error on Instagram Website

Server Error on Instagram Website

 

Server Error on Instagram Mobile App

Server Error on Instagram Mobile App

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Earthquake in Nalanda, Patna – Bihar with 3.5 Magnitude

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Earthquae

An earthquake of magnitude 3.5 was reported near Nalanda in Bihar on Monday night, according to India’s National Center for Seismology.

The epicenter of the earthquake was 20 km northwest (NW) of Nalanda, Bihar, India, the agency said. The earthquake struck at 9:23 PM IST at a depth of 5 km from the surface. Tremors were also felt in Gaya, Bhagalpur, Nalanda, Patna.

Earthquake Areas

Earthquake Areas

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Uttarakhand Power Plant Damaged After The Glacier Burst

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Chamoli Glacier Burst

Uttarakhand: A glacial burst in Chamoli district, Uttarakhand triggered an avalanche and massive flooding of the Alaknanda and Dhauliganga rivers on Sunday morning, forcing the emergency evacuation of thousands from surrounding areas, and damaging houses and the nearby Rishiganga power project.

Disaster response and management teams have been deployed to conduct search-and-rescue and relief operations. Around 100 to 150 people may have been killed, Uttarakhand Chief Secretary Om Prakash told news agency ANI. Authorities fear hundreds more may still be stuck. Prime Minister Narendra Modi, who is in Assam to campaign for Assembly polls, tweeted: “India stands with Uttarakhand and the nation prays for everyone’s safety.”

Disaster management teams have been mobilized and hundreds of ITBP (Indo-Tibetan Border Police) have been rushed for rescue operations.

SN Pradhan, chief of the National Disaster Response Force (NDRF), said that teams from the relief force have been moved for search-and-rescue and relief operations in Uttarakhand where a glacial burst has triggered an avalanche. “The glacial burst has taken out a bridge constructed by the Border Road Organisation. Also in the higher reaches, the Rishiganga hydel project also has been damaged,” he said.

 

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